GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs14978 | 1 | rs11974384 | chr7:12256540 | VWDE | chr7:12370509-12443852:- | -0.13 | -3.44 | 0.000599 | Response to amphetamines |
| BRCA | cis | rs9638182 | 1 | rs11974409 | chr7:72989390 | MLXIPL | chr7:73007524-73038870:- | 0.35 | 6.87 | 1.08E-11 | Triglycerides |
| BRCA | cis | rs11976180 | 1 | rs11975942 | chr7:143740580 | ARHGEF35 | chr7:143883677-143892736:- | -0.43 | -10.19 | 2.51E-23 | Obesity-related traits |
| BRCA | cis | rs11976180 | 1 | rs11975942 | chr7:143740580 | OR2A7 | chr7:143955790-143974852:- | 0.22 | 4.99 | 6.95E-7 | Obesity-related traits |
| BRCA | cis | rs11976180 | 1 | rs11975942 | chr7:143740580 | OR2A9P | chr7:143991573-143997832:+;chr7 | -0.14 | -3.41 | 0.000685 | Obesity-related traits |
| BRCA | cis | rs11976020 | 1 | rs11976020 | chr7:72247800 | SBDSP1 | chr7:72299952-72307976:+ | -0.22 | -5.21 | 2.3E-7 | Educational attainment (years of education) |
| BRCA | cis | rs11976020 | 1 | rs11976020 | chr7:72247800 | TYW1B | chr7:72023729-72298813:- | 1.02 | 29.56 | 8.46E-141 | Educational attainment (years of education) |
| BRCA | cis | rs11976180 | 1 | rs11976037 | chr7:143741024 | ARHGEF35 | chr7:143883677-143892736:- | -0.42 | -10.12 | 4.81E-23 | Obesity-related traits |
| BRCA | cis | rs11976180 | 1 | rs11976037 | chr7:143741024 | OR2A7 | chr7:143955790-143974852:- | 0.23 | 5.14 | 3.19E-7 | Obesity-related traits |
| BRCA | cis | rs11976180 | 1 | rs11976180 | chr7:143741580 | ARHGEF35 | chr7:143883677-143892736:- | -0.43 | -10.22 | 1.81E-23 | Obesity-related traits |
| BRCA | cis | rs11976180 | 1 | rs11976180 | chr7:143741580 | OR2A7 | chr7:143955790-143974852:- | 0.22 | 4.97 | 7.66E-7 | Obesity-related traits |
| BRCA | cis | rs11976180 | 1 | rs11976180 | chr7:143741580 | OR2A9P | chr7:143991573-143997832:+;chr7 | -0.14 | -3.49 | 0.000501 | Obesity-related traits |
| BRCA | cis | rs6964969 | 1 | rs11980407 | chr7:50471613 | FIGNL1 | chr7:50511834-50518088:- | -0.11 | -3.5 | 0.000479 | Acute lymphoblastic leukemia (childhood) |
| BRCA | cis | rs10808739 | 1 | rs11992601 | chr8:65696040 | CYP7B1 | chr8:65508529-65711348:- | 0.12 | 3.84 | 0.000131 | HIV-1 susceptibility |
| BRCA | cis | rs10808739 | 1 | rs11996540 | chr8:65668267 | CYP7B1 | chr8:65508529-65711348:- | 0.11 | 3.45 | 0.000584 | HIV-1 susceptibility |